Role of autonomic regulatory mechanism in sinoatrial conduction and sinus node automaticity in sick sinus syndrome.

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Role of autonomic regulatory mechanism in sinoatrial conduction and sinus node automaticity in sick sinus syndrome.

To assess the role of autonomic regulatory mechanisms on sinoatrial conduction and automaticity in patients with clinical evidence of sick sinus syndrome, electrophysiologic studies were conducted in 12 male patients, mean age 64 4 7 years. Heart rate, sinus node recovery time (SNRT) and sinoatrial conduction time (SACT) were determined before and after autonomic blockade with atropine (0.04 mg...

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Postural Tachycardia Syndrome and Inappropriate Sinus Tachycardia: Role of Autonomic Modulation and Sinus Node Automaticity

BACKGROUND Inappropriate sinus tachycardia (IST) and postural tachycardia syndrome (POTS) are 2 disorders characterized by sinus tachycardia. It is debated whether the pathophysiology of IST and POTS results from abnormal autonomic regulation or abnormal sinus node function. We hypothesized that intrinsic heart rate (IHR) after autonomic blockade would be increased in patients with IST but not ...

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Survival in sinoatrial disorder (sick-sinus syndrome).

A total of 381 patients with established (156) or potential (225) sinoatrial dysfunction were included in a 10-year prospective survey to determine the course of the disease and the benefits of pacing. With the exclusion of nine patients who were lost to follow-up, 61 were fitted with pacemakers. The overall survival of patients with established and potential dysfunction was similar and apparen...

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Influences of autonomic changes on the sinus node recovery time in patients with sick sinus syndrome.

To assess the relative contribution of sympathetic and vagal influences on diurnal variation of sinus node recovery time (SNRT) in sick sinus syndrome (SSS), the diurnal changes of SNRT and the effects of propranolol and subsequent atropine on SNRT were examined in 39 patients with SSS. SNRT was measured before and after intravenous propranolol (0.1 mg/kg), and after subsequent intravenous atro...

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Assessment by autonomic blockade of age-related changes of the sinus node function and autonomic regulation in sick sinus syndrome.

Age-related changes of the sinus node (SN) function and the autonomic influence on the SN function were evaluated in 65 patients with sick sinus syndrome (range 14 to 84 years). Heart rate (HR), corrected SN recovery time and sinoatrial conduction time were measured before (basic) and after (intrinsic) autonomic blockade (propranolol 0.2 mg/kg plus atropine 0.04 mg/kg intravenously). Percent of...

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ژورنال

عنوان ژورنال: Circulation

سال: 1981

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.64.4.832